Coagulation is the process by which a blood clot forms to reduce blood loss after damage to a blood vessel.
Coagulation is the process by which a blood clot forms to reduce blood loss after damage to a blood vessel. Several components of the coagulation cascade, including both cellular (e.g. platelets) and protein (e.g. fibrin) components, are involved in blood vessel repair.
• The coagulation cascade is a series of reactions, which leads to the formation of a clot
• Platelets release chemicals that cause a cascade reaction
• Prothrombin, thrombin, and fibrinogen are the main factors involved in the outcome of the coagulation cascade. Prothrombin and fibrinogen are proteins that are produced and deposited in the blood by the liver.
• Prothrombin is converted into thrombin which converts fibrinogen into fibrin.
• Fibrin forms an interlocking network of fibers that traps and helps hold platelets, blood cells, and other molecules tight to the site of injury, functioning as the initial clot.
• Coagulation involves a complex cascade in which a fibrin mesh is cleaved from fibrinogen.
• Fibrin acts as a “molecular glue” during clot formation, holding the platelet plug together.
fibrin: an elastic, insoluble, whitish protein produced by the action of thrombin on fibrinogen and forming an interlacing fibrous network in the coagulation of blood.
endothelium: a thin layer of flat epithelial cells that lines the heart, serous cavities, lymph vessels, and blood vessels
thrombin: the end product of the coagulation cascade, which cleaves fibrin from fibrinogen
fibrinogen: is converted enzymatically by thrombin to fibrin and then to a fibrin-based blood clot
platelets: tiny blood cells that help your body form clots to stop bleeding